Fig. 2. Enzymes associated with glucose metabolism that is regulated by YAP. Shown above are the enzymes associated with the glucose metabolism pathway, specifically glycolysis and gluconeogenesis. Several glucose transporters that are regulated by YAP is also shown. YAP was found to upregulate almost all glycolysis enzymes and downregulate gluconeogenesis enzymes. The dashed line denotes the cell membrane, which separates the cytosolic and the extracellular compartment. The mitochondrial compartment is separated from the cytosolic compartment by the thick black box. Glycolysis enzymes are shown by the single black-bordered boxes. Gluconeogenesis enzymes are shown by the double black-bordered boxes. Glucose transporter protein is shown by the rounded rectangle at the edge of the cell membrane. Green color denotes the enzymes which are upregulated by YAP. Red color denotes the enzymes which are downregulated by YAP. ALDO: Aldolase, ENO: Enolase, FBP: Fructose-Bisphosphatase, GAPDH: Glyceraldehyde-3-phosphate dehydrogenase, GPI: Glucose phosphate isomerase, G6PC: Glucose-6-phosphatase, HK: Hexokinase, LDH: Lactate Dehydrogenase, PCK: Phosphoenolpyruvate Carboxykinase, PFK: Phosphofructokinase, PGAM: Phosphoglyceromutase, PGK: Phosphoglycerate kinase, PK: Pyruvate Kinase, TPI: Triosephosphate isomerase.